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Quick Details

  • CAS No.: 1405-10-3
  • Other Names: Neomycinsulphate
  • MF: C23H46N6O13 3H2SO4
  • EINECS No.: /
  • Place of Origin: Henan, China (Mainland)
  • Type: Antiviral
  • Grade Standard: Medicine Grade
  • Usage: Animal Pharmaceuticals
  • Brand Name: Zzsigma
  • Model Number: Top Grade
  • Purity: 99%min
  • Appearance: White Powder

Packaging & Delivery

Packaging Details 25kg/drum
Delivery Time 3 days

Neomycin Sulfate / Neomycinsulphate / USP/EP/CVP/ CAS:1405-10-3

Neomycin sulphate

 

Pharmacodynamics:

Neomycin is an aminoglycoside antibiotic. It acts on the bacteria ribosome, inhibiting the synthesis of protein, strengthening cell membrane permeability, which causes the leakage of some important cell materials such as potassium ion, adenine and nucleotide, leading to the death of the cells. Neomycin is especially effective to the bacteria in rest stage. It has good antibacterial function on staphylococcus aureus and enterobacteriaceae (coli etc.). The bacteria may obtain resistance to neomycin, but the process is slow. There is also partial or complete cross-resistance between neomycin and streptomycin, kanamycin, or gentamicin

 

Pharmacokinetics:

Little of neomycin is absorbed if orally or locally applied. When orally applied, only 3% is excreted with urine and most is excreted with dejecta in original shape. A large amount can be absorbed when there is intestinal inflammation or abscess.   

 

Indications:It is indicated for the prevention and treatment of bacterial enteritis in calves, sheep, goats, swine and poultry caused by bacteria susceptible to neomycin, such as E. coli, Salmonella and Campylobacter spp.

 

Usage and dosage: Water-premix: poultry---50-75mg product/1 liter water, successive for 3-5 days.

 

Warning:Keep out of reach of children.

 

Specification of neomycin sulfate:

Test Item

Standard Specification

Test Data

Identification

a)       TLC

b)      Color reaction

c)      Sulfate reaction

Complies

Complies

Complies

Infrared absorption

According with IR reference spectrum

Meets the requirement

Loss on drying

≤8.0%

3.2%

 

PH

5.0-7.5

6.6

 

Residue on ignition

≤0.05%

Not more than 0.05% of weight

0.03%

 

Substances insoluble in sodium carbonate

The solution is clear

Clear

 

Partical size

0.5% max on USP sieve 180(um)

Meets the requirement

 

Heavy metals

≤10ppm

The limit is 10ug per g

10ppm

Assay

     Not less than 680 ug/mg

692ug/mg

 

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